Samantha Ruth Prabhu has been vocal about her broken marriage with co-star Naga Chaitanya, although she didn't mention him by name. She is expressing her views on her troubled phase. She also described the divorce as "challenging" and "really difficult." In the recently initiated health podcast, Sam has been vocal about her health issues and her personal life. She revealed her struggle with the autoimmune condition myositis. Sam took a break from work to focus on her health and launched a health podcast where she opened up about the difficulties she faced during that time. She emphasized prioritizing health and safety, especially in light of her ongoing health challenges.

Sam recalled a moment of calm before her health struggles while travelling back from Mumbai in June last year. She said on her podcast, "I remember specifically the year before I had this problem; it was an extremely difficult year for me. I specifically remember the day that I think my friend/partner/manager Himank, and I were traveling back from Mumbai. And this was in June of the year before last, and I remember telling him that finally, I feel calm. I haven’t felt a little relaxed and a little calm in a very, very long time. And I finally feel like I can breathe, and I can go to sleep, and I can now wake up and focus on my work and be the best that I can be at work. And I woke up with this condition."

She also explained why she wanted to do this podcast, "The reason I wanted to do this podcast was that after the harrowing experience that I’ve been through, and well, an autoimmune condition is lifelong, so with what I’m dealing with right now as well, I’d rather people be safe than sorry."

Meanwhile, Samantha has continued her professional endeavours, recently seen in 'Kushi' alongside Vijay Deverakonda and currently dubbing for 'Citadel', a project created by Raj and DK, where she stars alongside Varun Dhawan.

Samantha Ruth Prabhu and Naga Chaitanya got married in October 2017. The couple announced their separation in October 2021. On the work front, Samantha's recent projects include 'Kushi' with Vijay Deverakonda and 'Citadel' with Varun Dhawan, created by Raj and DK, for which she was dubbing.